Long-term vancomycin use had low risk of ototoxicity

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Is Vancomycin Ototoxicity a Significant Risk?

Forouzesh and colleagues recently reported an increase in vancomycin ototoxicity in parallel with the increasing use of higher vancomycin doses (4). The report suggests an overall incidence of vancomycin-induced ototoxicity of 12%, doubling historic estimates (3). This is a surprisingly high estimate for a drug that many experts do not consider to be ototoxic (5, 6). The authors have outlined s...

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Is vancomycin ototoxicity a significant risk?

Forouzesh and colleagues recently reported an increase in vancomycin ototoxicity in parallel with the increasing use of higher vancomycin doses (4). The report suggests an overall incidence of vancomycin-induced ototoxicity of 12%, doubling historic estimates (3). This is a surprisingly high estimate for a drug that many experts do not consider to be ototoxic (5, 6). The authors have outlined s...

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Long-term use of antibiotics and risk of colorectal adenoma.

OBJECTIVE Recent evidence suggests that antibiotic use, which alters the gut microbiome, is associated with an increased risk of colorectal cancer. However, the association between antibiotic use and risk of colorectal adenoma, the precursor for the majority of colorectal cancers, has not been investigated. DESIGN We prospectively evaluated the association between antibiotic use at age 20-39 ...

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Is Long-term Use of Benzodiazepine a Risk for Cancer?

The carcinogenicity of benzodiazepines (BZDs) is still unclear. We aimed to assess whether long-term benzodiazepines use is risk for cancer.We conducted a longitudinal population-based case-control study by using 12 years from Taiwan National Health Insurance database and investigated the association between BZDs use and cancer risk of people aged over 20 years. During the study period, 42,500 ...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2019

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0224561